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製品番号: HY-181582

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LASSBio-2382

LASSBio-2382 is a dual ROCK1/ROCK2 inhibitor with ROCK1 IC₅₀ of 0.005 μM and ROCK2 IC₅₀ of 0.003 μM. LASSBio-2382 inhibits viability and migration of cancer cells. LASSBio-2382 can be used for the research of triple-negative breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2487752-24-7
分子式: C₁₈H₁₅N₅O
分子量:317.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LASSBio-2382 構造式

CAS 番号: 2487752-24-7

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

ROCK1

0.05 μM (IC₅₀)

ROCK2

0.03 μM (IC₅₀)

ROCK アイソフォーム固有の製品をすべて表示 :

体外実験

LASSBio-2382 (Compound 17) potently inhibits both purified ROCK1 (IC₅₀ = 0.005 μM) and ROCK2 (IC₅₀ = 0.003 μM) in a cell-free biochemical assay^[1].
LASSBio-2382 is insoluble in the PAMPA-BBB assay, precluding measurement of its blood-brain barrier permeability^[1].
LASSBio-2382 (30 μM; 24 h) reduces MDA-MB-231 cell viability by 28.8%^[1].
LASSBio-2382 (0.1-100 μM; 24 h) inhibits MDA-MB-231 cell migration in a dose-dependent manner, with inhibition reducing wound closure to <50% at 10 μM and <25% at 30 μM, and precipitation observed at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay^[1]

Cell Line:

MDA-MB-231 human triple-negative breast adenocarcinoma cells
Concentration:

0.1 μM, 10 μM, 30 μM, 100 μM
Incubation Time:

24 h
Result:

Showed wound closure comparable to the control at 0.1 μM.
Reduced wound closure to less than 50% relative to the control at 10 μM.
Reduced wound closure to below 25% relative to the control at 30 μM.
Showed similar inhibition to 30 μM at 100 μM, with precipitation observed.

化学情報

CAS 番号 2487752-24-7
分子量 317.34
分子式 C₁₈H₁₅N₅O
SMILES

O=C(CC1=CNC2=C1C=CC=C2)N/N=C/C3=CC(C=NN4)=C4C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Pinheiro P S M, et al. Discovery of N-Acylhydrazone Derivatives as ROCK Inhibitors: A Journey from Virtual Screening and Structure-Based De Novo Design to the Identification of ROCK2 Selective Inhibitors and Beyond[J]. ACS Bio & Med Chem Au, 2026.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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LASSBio-2382

ROCK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

LASSBio-2382 関連分類

HY-181582 関連分類