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United States

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Total: USD 0.00 Checkout

製品番号: HY-P992534

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LEVI-04

LEVI-04 is a p75NTR-Fc fusion protein. LEVI-04 blocks and clears neurotrophins, binding excess NGF to block NGF activity, and binds NT-3 with high affinity to inhibit NT-3 activity. LEVI-04 inhibits NT-3-mediated TrkC receptor signaling and supplements endogenous p75NTR. LEVI-04 can be used in research on osteoarthritis and knee osteoarthritis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEVI-04 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Species Reactivity
- IC₅₀ & Target
- Target
- Conjugated
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Species Reactivity

Human

IC₅₀ & Target

^[1]

TrkC

Trk Receptor アイソフォーム固有の製品をすべて表示 :

Target

NT-3

Conjugated

Unconjugated

アプリケーション

ELISA, FACS, Functional assay

化学情報

SMILES

[LEVI-04]
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Fedotcheva TA, et al. Current State of the Neurotrophin-Based Pharmaceutics in the Treatment of Neurodegenerative Diseases and Neuroinflammation. Medical sciences (Basel, Switzerland). 2025 Dec 29;14(1):15. [Content Brief]

[2]. Conaghan P G, et al. OA04 A randomised controlled Phase II trial of LEVI-04, a novel neurotrophin-3 inhibitor, in knee osteoarthritis demonstrates substantially improved pain and function without deleterious effects on joint structure[J]. Rheumatology, 2025, 64(Supplement_3): keaf142. 004.

[3]. Conaghan P G, et al. LEVI-04, A NOVEL NEUROTROPHIN-3 INHIBITOR, SUBSTANTIALLY IMPROVES PAIN AND FUNCTION IN PEOPLE WITH KNEE OSTEOARTHRITIS: A RANDOMISED CONTROLLED PHASE II TRIAL[J]. Osteoarthritis and Cartilage, 2025, 33: S65-S66.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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