LH1306
LH1306 is a C2-symmetric inhibitor of PD-1/PD-L1 protein-protein interaction (PPI), with an IC50 value of 25 nM. LH1306 can be used in anti-tumor research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2182653-84-3
- 分子式: C38H48N6O6
- 分子量:684.82
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-132212
LH1307
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HY-134884
INCB086550
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HY-102011
BMS-1166
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HY-102011A
BMS-1166 hydrochloride
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HY-131347
PD-1/PD-L1-IN-NP19
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HY-101097
PD-1-IN-17
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HY-113008B
trans-Urocanic acid
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HY-163041
PD-1/PD-L1-IN-36
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HY-155959
PD-1/PD-L1-IN-33
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HY-102011R
BMS-1166 (Standard)
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HY-126877
3-Deaza-2'-deoxyadenosine
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HY-113008BR
trans-Urocanic acid (Standard)
生物活性
IC50: 25 nM (PD-1/PD-L1)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | GI50 |
3.1 μM
Compound: 2a
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Cytotoxicity against CHOK1 cells stably expressing human PDL1 co-cultured with human Jurkat T cell expressing human PD1 assessed as growth inhibition measured after 24 hrs by XTT assay
Cytotoxicity against CHOK1 cells stably expressing human PDL1 co-cultured with human Jurkat T cell expressing human PD1 assessed as growth inhibition measured after 24 hrs by XTT assay
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[PMID: 31298541] |
| HEK293 | IC50 |
25 nM
Compound: 2a
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Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 residues) expressed in HEK293 cells protein-protein interaction after 1 hr by APC-labeled anti-His antibody/Eu-
Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 residues) expressed in HEK293 cells protein-protein interaction after 1 hr by APC-labeled anti-His antibody/Eu-
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[PMID: 31298541] |
| Jurkat | EC50 |
334 nM
Compound: 2a
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Inhibition of PD1/PDL1 interaction in human Jurkat cells co-cultured with human U2OS cells expressing PDL1 assessed as reduction in SHP1 recruitment preincubated with U2OS cells for 60 mins followed by Jurkat cell addition and measured after 2 hrs by Path
Inhibition of PD1/PDL1 interaction in human Jurkat cells co-cultured with human U2OS cells expressing PDL1 assessed as reduction in SHP1 recruitment preincubated with U2OS cells for 60 mins followed by Jurkat cell addition and measured after 2 hrs by Path
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[PMID: 31298541] |
| Jurkat | EC50 |
4214 nM
Compound: 2a
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Inhibition of human PD1 stably expressed in human Jurkat T cells co-expressing NFAT-induced luciferase/human PDL1 stably expressed in CHOK1 cells co-expressing aAPC protein-protein interaction assessed as increase in NFAT signaling measured after 6 hrs by
Inhibition of human PD1 stably expressed in human Jurkat T cells co-expressing NFAT-induced luciferase/human PDL1 stably expressed in CHOK1 cells co-expressing aAPC protein-protein interaction assessed as increase in NFAT signaling measured after 6 hrs by
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[PMID: 31298541] |
| Jurkat | GI50 |
3.1 μM
Compound: 2a
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Cytotoxicity against human Jurkat T cell expressing human PD1 co-cultured with CHOK1 cells stably expressing human PDL1 assessed as growth inhibition measured after 24 hrs by XTT assay
Cytotoxicity against human Jurkat T cell expressing human PD1 co-cultured with CHOK1 cells stably expressing human PDL1 assessed as growth inhibition measured after 24 hrs by XTT assay
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[PMID: 31298541] |
化学情報
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CAS 番号 2182653-84-3
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分子量 684.82
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分子式 C38H48N6O6
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SMILES
CC(NCCNCC(C(OC)=N1)=CC=C1OCC2=CC=CC(C3=CC=CC(COC4=CC=C(C(OC)=N4)CNCCNC(C)=O)=C3C)=C2C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LH1306 関連分類
HY-132223 関連分類
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