LH17
LH17, a Kaempferol (HY-14590) derivative, is a potent and selective PDE4 inhibitor (PDE4D2 IC50 = 73 nM, PDE4B2 IC50 = 190 nM). LH17 exhibits remarkable selectivity (>136-fold) against other PDE isoforms (PDE1B/2A/3A/5A/8A/9A/10A) (IC50 > 10000 nM), with the exception of PDE7A1 (IC50 = 300 nM). LH17 distinctly interacts with PDE4 M-pocket. LH17 demonstrates remarkable anti-fibrotic efficacy in both in vitro and in vivo models. LH17 can be used for idiopathic pulmonary fibrosis (IPF) research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C28H25NO6
- 分子量:471.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
生物活性
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PDE4D2 73 nM (IC50) |
PDE4B2 190 nM (IC50) |
PDE7A1 300 nM (IC50) |
PDE1B2 >10000 nM (IC50) |
PDE2A >10000 nM (IC50) |
PDE3A >10000 nM (IC50) |
PDE5A1 >10000 nM (IC50) |
PDE7A1 >10000 nM (IC50) |
PDE8A1 >10000 nM (IC50) |
PDE9A1 >10000 nM (IC50) |
PDE10A1 >10000 nM (IC50) |
化学情報
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分子量 471.50
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分子式 C28H25NO6
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SMILES
CC1(C)OC2=CC3=C(C(C(OC)=C(C4=CC=C(OC)C=C4)O3)=O)C(OCC5=CC=NC=C5)=C2C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LH17 関連分類
HY-180803 関連分類
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