LM-4108
LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 261766-32-9
- 分子式: C27H25ClN2O3
- 分子量:460.95
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Human COX-2 60 nM (IC50) |
Ovine COX-1 >66 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
0.21 μM
Compound: LM-4108
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Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay
Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay
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[PMID: 20056549] |
| RAW264.7 | IC50 |
56.7 μM
Compound: LM-4108
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Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassay
Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassay
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[PMID: 20056549] |
化学情報
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CAS 番号 261766-32-9
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性状 Solid
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分子量 460.95
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分子式 C27H25ClN2O3
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Color White to off-white
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SMILES
O=C(N1C2=C(C(CC(NCCC3=CC=CC=C3)=O)=C1C)C=C(OC)C=C2)C4=CC=C(C=C4)Cl
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別名
N-(2-Phenylethyl)-indomethacin amide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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