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製品番号: HY-14408

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Lu AA47070

Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.

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CAS 番号: 913842-25-8
分子式: C₁₇H₂₀F₂N₃O₆PS
分子量:463.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Lu AA47070 構造式

CAS 番号: 913842-25-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Adenosine Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

Lu AA47070 (3.75, 7.5, 15, 30 mg/kg; i.p.) reverseS the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP)^[2].
Pharmacokinetic Parameters of Lu AA47070 in Sprague-Dawley rats^[1].

Compd	dose （mg/kg）	AUC(ng*h/L)	T_max (h)	C_max (ng/mL)	F (%)
32	1.5	2.9±0.7	0.5±0.1	869±68	55±13
32	15	35±3.0	0.4±0.2	6413±281	66±6

Sprague-Dawley rats, 1.5, 15 mg/kg po^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague Dawley rats^[2]
Dosage:

3.75, 7.5, 15, 30 mg/kg
Administration:

I.p.
Result:

Reversed the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP).

化学情報

CAS 番号 913842-25-8
分子量 463.39
分子式 C₁₇H₂₀F₂N₃O₆PS
SMILES

O=P(O)(O)OCN1C=CS/C1=N\C(C2=CC(F)=C(NC(CC(C)(C)C)=O)C(F)=C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Discovery of Phosphoric Acid Mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor Antagonist J. Med. Chem., Article ASAP DOI: 10.1021/jm1008659 Publication Date (Web): January 6, 2011

[2]. Collins LE, et al. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505. [Content Brief]

Calculators

モル濃度計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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