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United States

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製品番号: HY-184003

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LY3972406

LY3972406 is an orally active, selective Kv1.3 antagonist. LY3972406 acts on chronically stimulated effector memory T cells without affecting naive central memory T cells. LY3972406 induces mild, non-adverse skin irritation in Rattus norvegicus. LY3972406 is applicable for the research of autoimmune diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3071928-57-6
分子式: C₁₆H₂₃ClN₂O₄·1/2C₅H₈O₄·1/2H₂O
分子量:492.95

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LY3972406 構造式

CAS 番号: 3071928-57-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

Kv1.3

体内実験

LY3972406 (300 mg/kg/day; p.o.; daily; 28 days) at 300 mg/kg/day (administered as the HG salt) is well-tolerated in Sprague-Dawley rats over 28 days, with nonadverse salivation and equivalent exposure to the HCl salt form^[2].
LY3972406 (100 mg/kg; p.o.; single dose) achieves equivalent exposure to the HCl salt in female Sprague-Dawley rats, with slightly faster absorption^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male and female, aged 7 to 11 weeks, males 187 to 514 g, females 146 to 308 g)^[2]
Dosage:

300 mg/kg/day
Administration:

p.o.; daily; 28 days
Result:

Observed 100% survival.
Caused minor, nonadverse salivation (slight intensity, Days 8 through 22) at similar incidence and severity as the LY3972406-HCl group.
Resulted in exposure comparable to the HCl salt (within 20% by AUC and C_max) with no accumulation (R_AUC <1.2).

化学情報

CAS 番号 3071928-57-6
分子量 492.95
分子式 C₁₆H₂₃ClN₂O₄·1/2C₅H₈O₄·1/2H₂O
SMILES

ClC1=C(C)C=C(O)C([C@H](N)C2CCN(C([C@H](O)CO)=O)CC2)=C1.O=C(CCCC(O)=O)O.O.[1/2].[1/2]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Li X, et al. Development of a Scalable Manufacturing Process for Kv1. 3 Antagonist LY3972406 Hemiglutarate Hemihydrate[J]. Organic Process Research & Development, 2026.

[2]. Franklin KM, et al. Safety Evaluation of Glutaric Acid as a Novel Pharmaceutical Salt for First-In-Human Dosing. Toxicol Sci. 2026 May 21:kfag059. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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