m-PEG3-aldehyde
Based on 1 publication(s) in Google Scholar
m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
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- 純度 : 99.83%
- CAS 番号: 356066-46-1
- 分子式: C8H16O4
- 分子量:176.21
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保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 m-PEG3-aldehyde
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生物活性
製品説明
IC50 & Target
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PEGs |
体外実験
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. The binding affinities of anti-mPEGs depend more on the backbone lengths of the polymers and the hydrophobicities of their end-groups than on their resemblance to the methoxy terminus of the immunogenic polymer[1]. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG spacer increases solubility in aqueous media.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 356066-46-1
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性状 Liquid (Density: 0.995±0.06 g/cm3)
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分子量 176.21
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分子式 C8H16O4
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Color Colorless to light yellow
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SMILES
O=CCCOCCOCCOC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biosens Bioelectron
2026 Nov 1:311:118940. PMID: 42322945
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (567.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6750 mL | 28.3752 mL | 56.7505 mL | 141.8762 mL |
| 5 mM | 1.1350 mL | 5.6750 mL | 11.3501 mL | 28.3752 mL | |
| 10 mM | 0.5675 mL | 2.8375 mL | 5.6750 mL | 14.1876 mL | |
| 15 mM | 0.3783 mL | 1.8917 mL | 3.7834 mL | 9.4584 mL | |
| 20 mM | 0.2838 mL | 1.4188 mL | 2.8375 mL | 7.0938 mL | |
| 25 mM | 0.2270 mL | 1.1350 mL | 2.2700 mL | 5.6750 mL | |
| 30 mM | 0.1892 mL | 0.9458 mL | 1.8917 mL | 4.7292 mL | |
| 40 mM | 0.1419 mL | 0.7094 mL | 1.4188 mL | 3.5469 mL | |
| 50 mM | 0.1135 mL | 0.5675 mL | 1.1350 mL | 2.8375 mL | |
| 60 mM | 0.0946 mL | 0.4729 mL | 0.9458 mL | 2.3646 mL | |
| 80 mM | 0.0709 mL | 0.3547 mL | 0.7094 mL | 1.7735 mL | |
| 100 mM | 0.0568 mL | 0.2838 mL | 0.5675 mL | 1.4188 mL |
m-PEG3-aldehyde 関連分類
HY-124011 関連分類
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