Maurocalcine
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques.
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- CAS 番号: 269745-22-4
- 分子式: C156H270N56O46S6
- 分子量:3858.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Maurocalcine (100 nM, 24 h) increases the sensitivity of RyR2 to activating [Ca2+]i and decrease its sensitivity to inhibiting [Ca2+]i[1].
Maurocalcine (5 μM, 4 h/24 h) is absolutely no sign of significant cell toxicity for HEK293[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293
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Concentration:5, 10 μM
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Incubation Time:4, 24 h
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Result:Had absolutely no sign of significant cell toxicity for concentrations up to 5 μM whether the incubation time lasted 4 h or 24 h.
Exhibited only 8.0% cell toxicity for concentration of 10 μM and a 24 h incubation time.
化学情報
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CAS 番号 269745-22-4
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分子量 3858.55
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分子式 C156H270N56O46S6
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配列
Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Leu-Cys-Lys-Glu-Asn-Lys-Asp-Cys-Cys-Ser-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys-Arg (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)
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シーケンスの短縮
GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999. [Content Brief]
[2]. Altafaj X, et al. Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification. Biochem J. 2007 Sep 1;406(2):309-15. [Content Brief]
[3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Maurocalcine 関連分類
HY-P5114 関連分類
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