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製品番号: HY-182892

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MC4491

MC4491 is a selective LSD1/PRMT5 inhibitor, with an IC₅₀ of 0.152 μM against the LSD1/CoREST complex and an IC₅₀ of 0.043 μM against the PRMT5/MEP50 complex. MC4491 induces transcriptomic changes and splicing alterations in AML cells. MC4491 is applicable for the research of acute myeloid leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₅H₄₅N₇O₃
分子量:611.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MC4491 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

LSD1

0.152 μM (IC₅₀)

PRMT5

0.043 μM (IC₅₀)

Histone Demethylase アイソフォーム固有の製品をすべて表示 :

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

体外実験

MC4491 potently and selectively inhibits both LSD1/CoREST (IC₅₀ = 0.152 μM) and PRMT5/MEP50 (IC₅₀ = 0.043 nM) in biochemical assays, with minimal activity against PRMT1 and PRMT7^[1].
MC4491 (50 nM; 3 days) treatment of MV4-11 AML cells recapitulates the transcriptomic and alternative splicing changes induced by combined PRMT5 and LSD1 inhibition, including activation of myeloid differentiation pathways and suppression of cell cycle-related pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

分子量 611.78
分子式 C₃₅H₄₅N₇O₃
SMILES

NC1CC1C2=CC=C(C=C2)NC(CCN3CCC(CC3)NC4=CC(C(NC[C@@H](CN5CCC6=CC=CC=C6C5)O)=O)=CC=N4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Param NJ, et al. A synergistic interaction between PRMT5 and LSD1 inhibitors in AML. Sci Adv. 2026;12(13):eaea4059. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
プロトコル
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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MC4491

Histone Demethylase アイソフォーム固有の製品をすべて表示

Histone Methyltransferase アイソフォーム固有の製品をすべて表示