MCI-INI-3
Based on 1 publication(s) in Google Scholar
MCI-INI-3 is a selective ALDH1A3 inhibitor, with an IC50 of 0.46 μM and a Ki of 0.55 μM against hALDH1A3. MCI-INI-3 inhibits retinoic acid (HY-14649) biosynthesis. MCI-INI-3 can be used in research related to glioblastoma and glioma.
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- 純度: 99.23%
- CAS 番号: 1011366-31-6
- 分子式: C21H15N3O4
- 分子量:373.36
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 MCI-INI-3
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生物活性
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ALDH1A3 0.55 μM (Ki) |
ALDH1A1 78.2 μM (Ki) |
MCI-INI-3 (0-100 μM; 30 min) potently and selectively inhibits recombinant human ALDH1A3 (IC50 = 0.46 μM; Ki = 0.55 μM) with ~140-fold greater selectivity over recombinant human ALDH1A1 (Ki = 78.2 μM) via competitive inhibition of the aldehyde substrate[1].
MCI-INI-3 (0.015-15 μM; 15 min-6 day) potently inhibits ALDH activity in U87MG glioblastoma cells and GSC-326 mesenchymal glioma stem cells, with sustained inhibition lasting up to 6 days in GSC-326 cells[1].
MCI-INI-3 (15 μM; 5 day) reduces proliferation of both MES (GSC-83, GSC-326) and PN (GSC-19, GSC-84) glioma stem cells at 15 μM, but this effect is not ALDH1A3-specific, as shown by similar IC50 values in GSC-326 wild-type and ALDH1A3-knockout cells[1].
MCI-INI-3 (15 µM) reduces RA production in U87MG glioma stem cells at 15 µM but shows non-specific cytotoxicity against non-ALDH1A3-expressing glioma stem cell lines at the same concentration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GSC-83, GSC-326, GSC-19, GSC-84 glioma stem cells
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Concentration:15 μM; variable concentrations (dose-response assays)
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Incubation Time:5 day (15 μM treatment)
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Result:Reduced proliferation of MES GSCs (GSC-83 and GSC-326) and PN GSCs (GSC-19 and GSC-84, which do not express ALDH1A3) at 15 μM.
Showed IC50 values of 26.21 μM for GSC-326 wild-type cells and 28.21 μM for GSC-326 ALDH1A3-knockout cells, indicating the anti-proliferative effect is not ALDH1A3-specific.
化学情報
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CAS 番号 1011366-31-6
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性状 Solid
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分子量 373.36
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分子式 C21H15N3O4
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Color Light yellow to green yellow
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SMILES
O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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iScience
Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3. [Abstract]2025 Oct 3;28(11):113675. PMID: 41210994
溶剤 & 溶解度
DMSO : 6.67 mg/mL (17.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li J, et al. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Communications biology. 2021 Dec 21;4(1):1420. [Content Brief]
[2]. MacLean MR, et al. Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways. International journal of molecular sciences. 2024 Apr 07;25(7):4102. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6784 mL | 13.3919 mL | 26.7838 mL | 66.9595 mL |
| 5 mM | 0.5357 mL | 2.6784 mL | 5.3568 mL | 13.3919 mL | |
| 10 mM | 0.2678 mL | 1.3392 mL | 2.6784 mL | 6.6960 mL | |
| 15 mM | 0.1786 mL | 0.8928 mL | 1.7856 mL | 4.4640 mL |
MCI-INI-3 関連分類
HY-169884 関連分類
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