mcIRBP-9
mcIRBP-9 is an orally active NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1489241-80-6
- 分子式: C42H74N12O11
- 分子量:923.11
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
mcIRBP-9 (1 μmol kg?1; p.o.; single dose given after LPS challenge) suppresses LPS-induced renal NF-κB activity and systemic IL-1β production in NF-κB transgenic mice, demonstrating anti-inflammatory activity relevant to nephropathy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NF-κB transgenic (male, 6-week-old)[1]
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Dosage:1 μmol kg-1
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Administration:p.o.; single dose given after LPS challenge
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Result:Reduced serum IL-1β levels by 69.28 % compared to LPS-only controls.
Suppressed LPS-induced renal NF-κB-dependent luminescent intensities by 61.78 % compared to LPS-only controls.
化学情報
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CAS 番号 1489241-80-6
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分子量 923.11
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分子式 C42H74N12O11
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配列
Ile-Val-Ala-Arg-Pro-Pro-Thr-Ile-Gly
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シーケンスの短縮
IVARPPTIG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
mcIRBP-9 関連分類
HY-P11736 関連分類
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