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製品番号: HY-124885

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MD 220661

MD 220661 is a semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO) inhibitor, and serves as a major metabolite of MD 240928 in rat brain. MD 220661 acts as a substrate for SSAO and exhibits reversible, selective MAO-B inhibition in rat tissues; in the absence of semicarbazide, its inhibitory potency against MAO-A activity decreases with prolonged pre-incubation time. MD 220661 is applicable to studies related to enzyme-catalyzed metabolism.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 73423-35-5
分子式: C₁₇H₁₇ClN₂O₃
分子量:332.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MD 220661 構造式

CAS 番号: 73423-35-5

容量

価格（税別）

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

MAO-A

MAO-B

Monoamine Oxidase アイソフォーム固有の製品をすべて表示 :

MAO-A
MAO-B

体外実験

MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat aorta homogenates with an initial IC₅₀ of 3.0 μM, but its inhibitory potency decreases significantly with preincubation time, indicating it acts as both an inhibitor and substrate of the enzyme^[1].
MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat heart homogenates with an initial IC₅₀ of 1.9 μM, and its inhibitory potency decreases with preincubation time, consistent with it acting as both an inhibitor and substrate of the enzyme^[1].
MD 220661 inhibits monoamine oxidase A in rat aorta homogenates, and its inhibitory potency decreases significantly with preincubation time in the absence of semicarbazide, but only slightly in the presence of semicarbazide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

MD 220661 (10-50 mg/kg; i.v.; single dose) does not produce significant inhibition of rat heart SSAO activity when measured 15 minutes post-administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 73423-35-5
分子量 332.78
分子式 C₁₇H₁₇ClN₂O₃
SMILES

O=C1OC(CN1C2=CC=C(C=C2)OCC3=CC=CC(Cl)=C3)CN
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dostert P, et al. Inhibition of semicarbazide-sensitive amine oxidase by monoamine oxidase B inhibitors from the oxazolidinone series. The Journal of pharmacy and pharmacology. 1984 Nov;36(11):782-5. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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MD 220661

Monoamine Oxidase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MD 220661 関連分類

HY-124885 関連分類