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製品番号: HY-15210

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Meglitinide

Meglitinide is an ATP-sensitive potassium (K_ATP) channel inhibitor. Meglitinide exhibits IC₅₀ values of 0.26 μM, 0.53 μM and 1.6 μM against K_ATP channels containing SUR1, SUR2A and SUR2B, respectively, with a K_d value of 7 μM for both SUR1 and SUR2A, and a K_d value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close K_ATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 54870-28-9
分子式: C₁₇H₁₆ClNO₄
分子量:333.77

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Meglitinide 構造式

CAS 番号: 54870-28-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	Inhibition	-6.41 % Compound: MEGLITINIDE	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

体外実験

Meglitinide blocks recombinant Kir6.2/SUR1, Kir6.2/SUR2A, and Kir6.2/SUR2B K_ATP channels with similar affinities, with IC₅₀ values ranging from 0.26 to 1.6 μmol/l across the channel subtypes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 54870-28-9
分子量 333.77
分子式 C₁₇H₁₆ClNO₄
SMILES

O=C(C1=CC=C(CCNC(C2=CC(Cl)=CC=C2OC)=O)C=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Proks P, et al. Sulfonylurea stimulation of insulin secretion. Diabetes. 2002;51 Suppl 3:S368-S376. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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