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製品番号: HY-P991665

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MEN1112

(別名: OBT357NF; OBT357)

MEN1112 (OBT357NF; OBT357) is a defucosylated humanized monoclonal antibody targeting Bst1/CD157, with an EC₅₀ of 0.4 nM. MEN1112 binds to Bst1/CD157 on acute myeloid leukemia cells, triggers slow antigen internalization, induces antibody-dependent cell-mediated cytotoxicity, and mediates the lysis of acute myeloid leukemia cells and blasts. MEN1112 is applicable for research related to acute myeloid leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (259 KB)

MEN1112 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 臨床実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

BST1/CD157

体外実験

MEN1112 specifically binds to Bst1/CD157-positive cell lines with an EC₅₀ of 1 nM, and does not bind to Bst1/CD157-negative cell lines^[1].
MEN1112 binds to recombinant Bst1/CD157 antigen with an EC₅₀ of 0.4 nM^[1].
MEN1112 exhibits stronger high-affinity binding to both high- and low-affinity alleles of the CD16A Fc receptor on effector cells due to its defucosylated Fc domain^[1].
MEN1112 induces slow internalization of the Bst1/CD157 antigen on target cells, a property that helps enhance its ADCC efficacy^[1].
MEN1112 potently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) against U937 acute myeloid leukemia (AML) cells, with an EC₅₀ of 30-140 pM^[3].
MEN1112-mediated target cell lysis (20 h post-administration) is significantly enhanced upon the addition of 5% healthy donor serum to the co-culture system of healthy monocytes and autologous NK cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

遺伝子ID

683 [NCBI]

アクセッション番号

Q10588

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

アプリケーション

ELISA, FACS, Functional assay

化学情報

SMILES

N/A
別名

OBT357NF; OBT357
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (259 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Aud D, et al. MEN1112, a Novel Humanized De-Fucosylated Monoclonal Antibody with High Affinity and Specificity for Bst1/CD157 Antigen and Enhanced CD16 Binding. Blood. 2014 Dec 6;124(21):3607.

[2]. Venditti A, et al. MEN1112/OBT357, an Anti Bst1/CD157 Humanized Antibody Inducing Acute Myelogenous Leukemia (AML) Blast Depletion in an Autologous Ex Vivo Assay: A Potential New Targeted Therapy for AML. Blood. 2015;126(23):788.

[3]. Krupka C, et al. Targeting AML Using an Fc-Engineered BST1/CD157 Monoclonal Antibody. Blood. 2014 Dec 6;124(21):987.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

お問い合わせ在庫あり

Amount: USD 0.00

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 臨床実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
CAS 番号:
生物種:
純度:
数量:

MEN1112

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MEN1112 関連分類

HY-P991665 関連分類