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United States

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製品番号: HY-177733

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MG-Lin3

MG-Lin3 is a Lin28 molecular glue degrader. MG-Lin3 recruits the E3 ubiquitin ligase RNF126 to form a ternary complex, induces the degradation of Lin28 via the ubiquitin-proteasome pathway, and restores the levels of mature let-7 miRNA. MG-Lin3 can be used in research on ovarian cancer, ovarian teratocarcinoma, and uterine cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₀H₃₀N₆O₄
分子量:538.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

MG-Lin3 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

MG-Lin3 (0.1-100 μM; 24 h) is a potent molecular glue degrader that promotes Lin28 degradation and restores let-7 activity in transfected PA-1 ovarian cancer cells, with a significant reduction in luciferase signal observed even at a concentration of 0.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

化学情報

分子量 538.60
分子式 C₃₀H₃₀N₆O₄
SMILES

COC1=CC=C(C=C1)C(/C=C/C(N2CCC(CC2)C(N(C3=CC=CC(C4=NN5C(C)=NN=C5C=C4)=C3)C)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kashkush A, et al. PROTAC and Molecular Glue Degraders of the Oncogenic RNA Binding Protein Lin28. Macromolecular bioscience. 2025 Mar;25(3):e2400427. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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