MG-T-19
Based on 1 Customer Validation
MG-T-19 is a potent small-molecule inhibitor targeting human TIM-3. MG-T-19 blocks the interactions between TIM-3 and its ligands such as phosphatidylserine, CEACAM1 and Galectin-9. MG-T-19 promotes the secretion of TNF-α and IFN-γ by peripheral blood mononuclear cells, and significantly enhances their ability to inhibit cancer cell proliferation. MG-T-19 can be used in studies related to acute myeloid leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.34%
- CAS 番号: 328540-44-9
- 分子式: C18H8Br2ClF3N4O2S
- 分子量:596.60
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
MG-T-19 (2.5 μM) significantly inhibits the interactions of human TIM-3 with PtdSer, CEACAM1, and Gal-9 in cell-free and cell-based ligand binding assays[1].
MG-T-19 (2.5 μM; 48 h) pretreatment of healthy donor PBMCs increases TNF-α and IFN-γ production following stimulation[1].
MG-T-19 (2.5 μM; 6 days) incubation of Kasumi-1 acute myelogenous leukemia cells with healthy donor PBMCs significantly reduces Kasumi-1 cell proliferation[1].
MG-T-19 binds to purified human TIM-3 with a Kd of 0.26 μM and inhibits TIM-3 interactions with its ligands PtdSer, CEACAM-1, and galectin-9[2].
MG-T-19 enhances TNF-α and IFN-γ secretion by healthy donor peripheral blood mononuclear cells and boosts inhibition of Kasumi-1 cell proliferation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Kasumi-1 acute myelogenous leukemia cells, peripheral blood mononuclear cells (PBMCs) from healthy donors
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Concentration:2.5 μM
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Incubation Time:6 days; 16 h (H3 thymidine labeling)
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Result:Augmented the capacity of PBMCs to impede the proliferation of Kasumi-1 cells, resulting in significantly reduced H3 thymidine uptake compared to coculture controls.
化学情報
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CAS 番号 328540-44-9
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性状 Solid
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分子量 596.60
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分子式 C18H8Br2ClF3N4O2S
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Color Light yellow to yellow
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SMILES
OC1=C(NC(C2=NN3C(N=C(C4=CC(Br)=CS4)C=C3C(F)(F)F)=C2Br)=O)C=C(Cl)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 14.29 mg/mL (23.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Abdel-Rahman SA, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints. Science advances. 2024 Oct 18;10(42):eadq5540. [Content Brief]
[2]. Wang L, et al. TIM-3 Inhibitor Development: Overcoming Immune Evasion in Cancer Therapy. Journal of medicinal chemistry. 2025 Dec 25;68(24):25754-25771. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6762 mL | 8.3808 mL | 16.7617 mL | 41.9041 mL |
| 5 mM | 0.3352 mL | 1.6762 mL | 3.3523 mL | 8.3808 mL | |
| 10 mM | 0.1676 mL | 0.8381 mL | 1.6762 mL | 4.1904 mL | |
| 15 mM | 0.1117 mL | 0.5587 mL | 1.1174 mL | 2.7936 mL | |
| 20 mM | 0.0838 mL | 0.4190 mL | 0.8381 mL | 2.0952 mL |
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