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United States

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製品番号: HY-118968

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(-)-SA2572

(-)-SA2572 is an orally active Ca²⁺ inward channel inhibitor. (-)-SA2572 inhibits the slow Ca²⁺ inward channel and the fast Na⁺ inward channel. (-)-SA2572 inhibits depolarization-induced contraction of gastrointestinal smooth muscle and vascular smooth muscle, prolongs atrioventricular nodal conduction time, and inhibits His bundle-ventricular conduction time. (-)-SA2572 reduces systolic blood pressure in spontaneously hypertensive rats. (-)-SA2572 can be used in the research of hypertension.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 112946-90-4
分子式: C₃₂H₄₁ClN₂O₆S
分子量:617.20

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-SA2572 構造式

CAS 番号: 112946-90-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Calcium Channel アイソフォーム固有の製品をすべて表示 :

体外実験

(-)-SA2572 (compound (-)-1) potently inhibits Ca²⁺-induced contraction in isolated guinea pig caecal bands and potently inhibits Ca²⁺-induced contraction in isolated rabbit aortic strips, with higher potency than its (+)-enantiomer ^[1].
(-)-SA2572 prolongs the A-H interval and H-V interval conduction time in isolated rabbit hearts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

(-)-SA2572 (compound (-)-1) (100 mg/kg; p.o.; single dose) produces a sustained hypotensive effect in conscious spontaneously hypertensive rats, with activity lasting up to 24 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 112946-90-4
分子量 617.20
分子式 C₃₂H₄₁ClN₂O₆S
SMILES

CC(N1[C@H](C2=C(C=CC(OC)=C2)OCCCCN(C)CCC3=CC(OC)=C(C(OC)=C3)OC)SC4=CC=CC=C41)=O.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Fujita M, et al. Synthesis and calcium antagonistic activity of (+)-(R)- and (-)-(S)-3-acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5- trimethoxyphenethyl)amino]butoxy]phenyl]benzothiazoline hydrochloride. Chemical & pharmaceutical bulletin. 1990 Apr;38(4):936-41.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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