Miro1 Reducer
Based on 1 Customer Validation
Miro1 Reducer is a small molecule that can repair this defect of Miro1 in Parkinson's disease (PD) fibroblasts. Miro1 Reducer reduces the delayed mitophagy phenotype in PD fibroblasts. Miro1 Reducer reduces Miro1 protein levels in dose-dependent manner (IC50 = 7.8 mM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.27%
- CAS 番号: 2624336-91-8
- 分子式: C20H17ClFN7O
- 分子量:425.85
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Miro1 Reducer (10 μM; 30 h) promotes Miro1 degradation following CCCP (HY-100941) treatment in fibroblasts from a sporadic PD patient[1].
Miro1 Reducer (5 μM; 30 h) can completely rescue stress-induced neurodegeneration in dopaminergic neurons derived from PD patients[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2624336-91-8
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性状 Solid
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分子量 425.85
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分子式 C20H17ClFN7O
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Color Off-white to yellow
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SMILES
O=C(NC1=CC(F)=CC=C1)NC2=CC=C(NC3=NC=NC(N4C=NC=C4)=C3)C=C2.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 62.5 mg/mL (146.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
ホットトピック
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All
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Topics
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Most Recent
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Oldest
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Topics Mitophagy: A Central Target in Neurodegenerative Diseases
Mitophagy is a selective form of autophagy that eliminates damaged or dysfunctional mitochondria and thereby preserves mitochondrial quality control, cellular homeostasis, and neuronal survival.
2026-06-18
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Topics When Mitophagy Becomes An Innate Immune Checkpoint
Mitophagy becomes an innate immune checkpoint when selective autophagic removal of damaged mitochondria regulates the availability of mitochondrial danger signals that activate innate immune pathways.
2026-06-18
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3482 mL | 11.7412 mL | 23.4824 mL | 58.7061 mL |
| 5 mM | 0.4696 mL | 2.3482 mL | 4.6965 mL | 11.7412 mL | |
| 10 mM | 0.2348 mL | 1.1741 mL | 2.3482 mL | 5.8706 mL | |
| 15 mM | 0.1565 mL | 0.7827 mL | 1.5655 mL | 3.9137 mL | |
| 20 mM | 0.1174 mL | 0.5871 mL | 1.1741 mL | 2.9353 mL | |
| 25 mM | 0.0939 mL | 0.4696 mL | 0.9393 mL | 2.3482 mL | |
| 30 mM | 0.0783 mL | 0.3914 mL | 0.7827 mL | 1.9569 mL | |
| 40 mM | 0.0587 mL | 0.2935 mL | 0.5871 mL | 1.4677 mL | |
| 50 mM | 0.0470 mL | 0.2348 mL | 0.4696 mL | 1.1741 mL | |
| 60 mM | 0.0391 mL | 0.1957 mL | 0.3914 mL | 0.9784 mL | |
| 80 mM | 0.0294 mL | 0.1468 mL | 0.2935 mL | 0.7338 mL | |
| 100 mM | 0.0235 mL | 0.1174 mL | 0.2348 mL | 0.5871 mL |
Miro1 Reducer 関連分類
HY-163172 関連分類
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