MitoBloCK-1
Based on 1 Customer Validation
MitoBloCK-1 (MB-1) is a TIM22 inhibitor. MitoBloCK-1 inhibits substrate translocation by preventing substrate binding to the tim9/10 complex, thereby preventing substrates from reaching the TIM22 translocase. MitoBloCK-1 inhibits the import of TIM22 substrate proteins into mitochondria. MitoBloCK-1 can be used in research on cardiac arrhythmia and P. aeruginosa infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.87%
- CAS 番号: 373370-73-1
- 分子式: C14H14BrN3O2S
- 分子量:368.25
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
MitoBloCK-1 blocks AAC translocation at an early outer-membrane stage by impairing Tim9-Tim10 complex binding in tim10-1 tim9S mitochondria[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CF-1 (female)[2]
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Dosage:50 mg/kg
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Administration:every 3 h; for 24 h
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Result:Reduced the P. aeruginosa UC12120 population only by approximately 1 log at 24 h.
Some killing effects were observed after repeated dosing at the 18- and 21-h time points.
No recoverable resistant colonies were detected when mouse thigh samples were plated onto MHB plates containing 0.5, 1, and 2 µg/mL.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 373370-73-1
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性状 Solid
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分子量 368.25
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分子式 C14H14BrN3O2S
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Color Off-white to light yellow
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SMILES
S=C(N/N=C/C1=C2C(CCCC3)=C3OC2=CC(Br)=C1O)N
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別名
MB-1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 1 mg/mL (2.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (282 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[3]. Hasson SA, et al. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proceedings of the National Academy of Sciences of the United States of America. 2010 May 25;107(21):9578-83. [Content Brief]
[4]. Ding YY, et al. Design, Synthesis, and Antimicrobial Activity Evaluation of Novel Isocryptolepine Derivatives against Phytopathogenic Fungi and Bacteria. Journal of agricultural and food chemistry. 2024 Sep 25;72(38):20831-20841. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7155 mL | 13.5777 mL | 27.1555 mL | 67.8887 mL |
MitoBloCK-1 関連分類
HY-122658 関連分類
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