MitoCur-1
Based on 1 publication(s) in Google Scholar
MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : ≥95.0%
- 分子式: C65H64Cl2O6P2
- 分子量:1074.05
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 MitoCur-1
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生物活性
製品説明
IC50 & Target
Thioredoxin reductase 2 (TrxR2)[1]
体外実験
MitoCur-1 exhibits selective cytotoxicity against HepG2 and L02 cells with IC50s of 1.4 μM and 9.1 μM, respectively[1].
MitoCur-1 (10 μM; 12 h) generates ROS and depletes GSH selectively in HepG2 cells over L02 cells[1].
MitoCur-1 (10 μM; 24 h) arrests cell cycle at G0/G1 phase, inhibits cyclin protein expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:2.5 μM, 5 μM, and 10 μM
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Incubation Time:24 h, 36 h, and 48 h
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Result:Decreased the protein level of CDK2 and CDK4, Cyclin E1/D1/A2.
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Cell Line:HepG2 and L02 cells
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Concentration:10 μM
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Incubation Time:12 h
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Result:Showed selectivity on HepG2 cells over L02 cells to generates ROS. Promoted mitochondrial O2- production.
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Cell Line:HepG2 cells
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Concentration:1.25 μM, 2.5 μM, 5 μM, and 10 μM
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Incubation Time:48 h; pretreated with 400 μM DTT or not
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Result:Inhibited HepG2 cells viability. Showed significant reversion with DTT for 1 h pretreatment.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice bearing HepG2 tumor[1]
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Dosage:5 mg/kg, 15 mg/kg
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Administration:Intraperitoneal injection; every other day for 4 weeks
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Result:Decreased the tumor growth in vivo.
化学情報
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性状 Solid
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分子量 1074.05
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分子式 C65H64Cl2O6P2
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Color Light yellow to orange
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SMILES
O=C(C(C(/C=C/C1=CC=C(OCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(OC)=C1)=O)(C)C)/C=C/C5=CC(OC)=C(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)C=C5.[Cl-].[Cl-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy. [Abstract]2026 Apr;13(22):e21997. PMID: 41704008
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MitoCur-1 関連分類
HY-150228 関連分類
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