MODAG-005
MODAG-005 is a blood-brain barrier-permeable PET probe precursor for α-synuclein (α‑Syn) aggregates, with a Ki value of 0.4 nM and a Kd value of 0.2 nM. MODAG-005 specifically binds to high-affinity sites within the tubular cavity of α-synuclein fibrils, and exhibits selectivity over tau protein fibrils and β-amyloid (A1-42) fibrils. MODAG-005 is applicable to the research of multiple system atrophy and Parkinson's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2648041-73-8
- 分子式: C15H13BrN4
- 分子量:329.19
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
α-synuclein アイソフォーム固有の製品をすべて表示
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生物活性
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α-synuclein Aggregation 0.2 nM (Kd) |
MAO-B 0.8 μM (IC50) |
[3H]MODAG-005 exhibits subnanomolar binding affinity for recombinant human α-synuclein fibrils, shows 36-fold lower affinity for tau fibrils and over 100-fold lower affinity for Aβ1-42 fibrils, with an MAO-B IC50 of 0.8 μM and no other relevant off-target binding[1].
[3H]MODAG-005 binds specifically to α-synuclein pathology in post-mortem human multiple system atrophy (MSA) brain tissues, with a high-affinity binding site (Kd = 0.19 nM); it shows no specific binding in control brain tissues and does not bind to monoamine oxidase B (MAO-B) in MSA tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[11C]MODAG-005 (intravenous administration; single bolus injection) binds specifically to α-synuclein fibrils in rats with striatal injections[1].
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits specific, pathology-associated binding to intracellular α-synuclein aggregates in α-SynA30P transgenic mice[1].
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits favorable pharmacokinetic properties in healthy cynomolgus monkeys, including rapid brain uptake, rapid clearance, and detectable plasma metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2648041-73-8
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分子量 329.19
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分子式 C15H13BrN4
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SMILES
CNC1=CC=C(C=C1)C2=NNC(C3=CC=NC(Br)=C3)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MODAG-005 関連分類
HY-184511 関連分類
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