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製品番号: HY-180547

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MRC71

MRC71 is a TRIMTAC degrader that recruits endogenous TRIM21 E3 ligase at one end and covalently binds to HaloTag-fusion target proteins at the other end. MRC71 selectively degrades oligomeric CAV1- and Cavin1-mEGFP-Halo, but not monomeric mEGFP-Halo, and exhibits a typical concentration-dependent degradation profile with a hook effect. MRC71 can be used to verify TRIMTAC ternary complex formation and state-selective degradation in cells.

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CAS 番号: 3070832-68-4
分子式: C₄₃H₆₆ClN₅O₈
分子量:816.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MRC71 構造式

CAS 番号: 3070832-68-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

MRC71 (2.5-20 μM) drives the formation of a ternary complex between purified TRIM21 PRYSPRY and HaloTag protein in vitro, with a characteristic hook effect occurring at excessively high compound concentrations^[1].
MRC71 (0.001-100 μM; 2 h) induces the formation of a dose-dependent ternary complex between full-length TRIM21 and H₂B-mEGFP-Halo in RPE-1 cells, with a hook effect occurring at excessively high compound concentrations^[1].
MRC71 (0.01-100 μM; 48 h) is a TRIM21-dependent TRIMTAC that selectively degrades oligomerized CAV1-mEGFP-Halo and Cavin1-mEGFP-Halo in RPE-1 cells, but does not affect monomeric mEGFP-Halo^[1].
MRC71 (2.5 μM; 24 h) selectively degrades membrane-associated oligomeric Cavin1-mEGFP-Halo via the proteasome in RPE-1 cells, while preserving the cytoplasmic monomer pool and smaller Cavin1-free cleavage products^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3070832-68-4
分子量 816.47
分子式 C₄₃H₆₆ClN₅O₈
SMILES

O=C(C[C@H](N)C1=C(OC)C=CC=C1)N(C2)[C@H](C(N[C@@H](CC3=CC=NC=C3)C(NCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H]2C4CCCCC4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Luptak J, Clift D, Mukadam A, et al.. State-selective small molecule degraders that preferentially remove aggregates and oligomers. Nature communications. 2025 Nov 25;16(1):10486. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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