MS8588
MS8588 is a deubiquitinase-targeting chimera (DUBTAC) against cGAS. MS8588 induces targeted stabilization of cGAS, thereby activating downstream signaling pathways. MS8588 activates the cGAS/STING/IRF3 innate immune signaling pathway. MS8588 exhibits antitumor activity.
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- CAS 番号: 3060519-94-7
- 分子式: C45H59Cl2N9O6S
- 分子量:924.98
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MS8588 (0-10 μM; 0-24 h) stabilizes cGAS and activates the cGAS/STING/IRF3 signaling pathway in HeLa cells in a concentration-, time-, cGAS- and OTUB1-dependent manner, without altering the expression level of cGAS mRNA; its stabilizing effect on cGAS reaches a peak when acting at 5 μM for 24 h[1].
MS8588 (5 μM; 2-14 days) effectively inhibits the proliferation and colony-forming ability of HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:5 μM
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Incubation Time:2 days (proliferation assay); 2 weeks (clonogenicity assay)
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Result:Significantly suppressed cell proliferation compared to vehicle control at 5 μM for 2 days.
Drastically reduced cell colony formation at 5 μM for 2 weeks.
化学情報
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CAS 番号 3060519-94-7
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分子量 924.98
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分子式 C45H59Cl2N9O6S
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SMILES
ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CCNC(CCCCCCCCCC(NCCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MS8588 関連分類
HY-162967 関連分類
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