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製品番号: HY-181282

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MSU-44147

MSU-44147 is an inhibitor and antimicrobial agent targeting MmpL3 in Mycobacterium abscessus, with low eukaryotic cytotoxicity, a narrow antimicrobial spectrum that is specific only to mycobacteria, and low drug resistance frequency. MSU-44147 reduces trehalose dimycolate levels by inhibiting MmpL3 function, disrupts biofilm formation and reduces the viability of related bacteria, while exerting bactericidal effects on intracellular Mycobacterium abscessus. MSU-44147 exhibits additive or synergistic effects with antibiotics and can be used in research on multidrug-resistant isolates and infections of Mycobacterium abscessus.

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CAS 番号: 3105177-29-2
分子式: C₁₇H₂₂F₃NO
分子量:313.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

MSU-44147 構造式

CAS 番号: 3105177-29-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

MSU-44147 (80 μM-0.08 nM; 3 d) potently inhibits the growth of Mycobacterium abscessus ATCC 19977 in vitro and exhibits time-dependent bactericidal activity at a concentration of 5× MIC. Meanwhile, it potently inhibits strains of Mycobacterium tuberculosis, Mycobacterium abscessus and Mycobacterium smegmatis, shows no activity against non-mycobacterial species within 80 μM, and displays variable inhibitory activity against clinically isolated multidrug-resistant Mycobacterium abscessus strains^[1].
MSU-44147 (0.18 nM-160 μM; 3 d) disrupts mature Mycobacterium abscessus biofilms with an EC₅₀ of 1.96 μM; while also reduces bacterial viability within biofilms, with a corresponding EC₅₀ of 0.18 μM^[1].
MSU-44147 (1-160 μM; 3 d) does not kill non-replicating, nutrient-starved Mycobacterium abscessus ATCC 19977 at concentrations up to 160 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
Concentration:

80 μM-0.08 nM
Incubation Time:

3 d
Result:

Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC₅₀ of 0.46 μM and a MIC of 8.15 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC₅₀value of 0.19 to 0.26 μM), Mycobacterium abscessus (EC₅₀ of 0.46 μM), and Mycobacterium smegma (EC₅₀ of 4.16 μM).

化学情報

CAS 番号 3105177-29-2
分子量 313.36
分子式 C₁₇H₂₂F₃NO
SMILES

CC1(CCCCC1)C(NCCC2=CC=C(C(F)(F)F)C=C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (282 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Abdalla BJ, et al. Defining the Mechanism of Action and Resistance of New Mycobacterium abscessus MmpL3 Inhibitors. ACS Chem Biol. 2026 Feb 20;21(2):284-301. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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