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製品番号: HY-115443

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MZH29

MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2089590-80-5
分子式: C₃₁H₃₃FN₄O₅
分子量:560.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

MZH29 構造式

CAS 番号: 2089590-80-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.17 nM Compound: 10; MZH29	Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835H Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835H	[PMID: 33719439]
BaF3	IC₅₀	0.19 nM Compound: 10; MZH29	Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835Y Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835Y	[PMID: 33719439]
BaF3	IC₅₀	0.22 nM Compound: 10; MZH29	Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD	[PMID: 33719439]
BaF3	IC₅₀	1.1 nM Compound: 10; MZH29	Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-F691L Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-F691L	[PMID: 33719439]
BaF3	IC₅₀	2.5 nM Compound: 10; MZH29	Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V	[PMID: 33719439]
BaF3	IC₅₀	22 nM Compound: 10; MZH29	Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-D835Y Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-D835Y	[PMID: 33719439]
MOLM-13	IC₅₀	0.24 nM Compound: MZH29	Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32659083]
MOLM-14	IC₅₀	0.13 nM Compound: 10; MZH29	Antiproliferative activity against human MOLM-14 cells Antiproliferative activity against human MOLM-14 cells	[PMID: 33719439]
MV4-11	IC₅₀	0.14 nM Compound: 10; MZH29	Cytotoxicity against human MV4-11 cells Cytotoxicity against human MV4-11 cells	[PMID: 33719439]
MV4-11	IC₅₀	0.14 nM Compound: MZH29	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32659083]

体内実験

MZH29 (1 mg/kg, p.o.) causes complete tumor regression and extends survival in a mouse model of AML with less toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2089590-80-5
分子量 560.62
分子式 C₃₁H₃₃FN₄O₅
SMILES

O=C(NC1=CC=CC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OCCCN5CCOCC5)=C(OC)C=C34)C(F)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Animals and Diseases

Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xu B, et al. MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia. Leukemia. 2017 Apr;31(4):913-921. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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