Nec-34i
Nec-34i is an inactive analog structurally similar to Nec-34 (HY-132203). Nec-34i has no effect on RIPK1 kinase activity and cannot inhibit necroptosis.
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- CAS 番号: 2212541-00-7
- 分子式: C21H19N3O2S
- 分子量:377.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Nec-34i (20 μM; 1 h) does not bind to or stabilize recombinant human RIPK1 kinase domain (residues 1-330) in a protein thermal shift assay[1].
Nec-34i (20 μM; 10 min) does not inhibit the in vitro kinase activity of human RIPK1 kinase domain (residues 1-330) from transfected 293T cells[1].
Nec-34i (10 μM) does not inhibit TNFα-induced necroptosis in FADD-deficient Jurkat cells or zVAD.fmk-induced necroptosis in L929 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2212541-00-7
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分子量 377.46
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分子式 C21H19N3O2S
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SMILES
N#CC1=C(NC(CC1C2=CC=C(C)C=C2)=O)SCC(NC3=CC=CC=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nec-34i 関連分類
HY-W674387 関連分類
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