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製品番号: HY-156467

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Neladalkib

Name: Neladalkib
Brand: MedChemExpress
SKU: HY-156467
Price: 170.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: NVL-655)

カスタマーレビュー

Based on 1 Customer Validation

Neladalkib (NVL-655) is an oral ALK inhibitor, the IC₅₀ for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.87%
CAS 番号: 2739866-40-9
分子式: C₂₃H₂₂ClFN₆O
分子量:452.91

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Neladalkib 構造式

CAS 番号: 2739866-40-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Neladalkib (NVL-655) is an oral ALK inhibitor, the IC₅₀ for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity^[1]^[2].

体外実験

Neladalkib has an IC₅₀ of 2.7 nM in Ba/F3 CLIP1-LTK cells^[1].
Neladalkib has a strong inhibitory effect on ALK^T1151insT, ALK^T1151M, ALK^L1152R, ALK^C1156Y, ALK^I1171N, ALK^I1171S, ALK^I1171T, ALK^F1174L, ALK^F1174S, ALK^V1180L, ALK^L1198F, ALK^G1202R, ALK^D1203N, ALK^S1206R, and ALK^R1275Q (IC₅₀ = 0.9-6.8 nmol/L), while it has a weaker inhibitory effect on ALK^G1196M, ALK^G1269A, and ALK^G1269S (IC₅₀ = 11-79 nmol/L)^[2].
Neladalkib (1-100 nM, 24 h) increases the activation of caspase 3/7 and reduces the S-phase cells in NCI-H3122^[2].
Neladalkib (1-100 nM, 24 h) promotes apoptosis in NCI-H3122 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

NCI-H3122
Concentration:

1, 10, 100 nM
Incubation Time:

24 h
Result:

Increased annexin V and propidium iodide (PI) staining.

Cell Cycle Analysis^[2]

Cell Line:

NCI-H3122
Concentration:

1, 10, 100 nM
Incubation Time:

24 h
Result:

Reduced S phase cells.

体内実験

Neladalkib (0.06-1.5 mg/kg, orally, twice daily, days 0-28) has antitumor activity in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ALK-driven tumor xenografts in mice^[2]
Dosage:

0.06, 0.2, 0.5, 1.5 mg/kg
Administration:

Oral
Result:

Inhibited tumor proliferation.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2739866-40-9
性状 Solid
分子量 452.91
分子式 C₂₃H₂₂ClFN₆O
Color White to off-white
SMILES

CCN1C2=C(C(Cl)=N1)CC3=CN(C)N=C3C4=CC=C(F)C=C4[C@H](OC5=C(N)N=CC2=C5)C
別名

NVL-655
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (220.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2079 mL

11.0397 mL

22.0794 mL

5 mM

0.4416 mL

2.2079 mL

4.4159 mL

10 mM

0.2208 mL

1.1040 mL

2.2079 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jennifer Anne Green, et al. Methods of treating solid tumor using (19r)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine. WO2023196910A1.

[2]. Jessica J Lin, et al. NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. Cancer Discov. 2024 Sep 13:OF1-OF20. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2079 mL	11.0397 mL	22.0794 mL	55.1986 mL
	5 mM	0.4416 mL	2.2079 mL	4.4159 mL	11.0397 mL
	10 mM	0.2208 mL	1.1040 mL	2.2079 mL	5.5199 mL
	15 mM	0.1472 mL	0.7360 mL	1.4720 mL	3.6799 mL
	20 mM	0.1104 mL	0.5520 mL	1.1040 mL	2.7599 mL
	25 mM	0.0883 mL	0.4416 mL	0.8832 mL	2.2079 mL
	30 mM	0.0736 mL	0.3680 mL	0.7360 mL	1.8400 mL
	40 mM	0.0552 mL	0.2760 mL	0.5520 mL	1.3800 mL
	50 mM	0.0442 mL	0.2208 mL	0.4416 mL	1.1040 mL
	60 mM	0.0368 mL	0.1840 mL	0.3680 mL	0.9200 mL
	80 mM	0.0276 mL	0.1380 mL	0.2760 mL	0.6900 mL
	100 mM	0.0221 mL	0.1104 mL	0.2208 mL	0.5520 mL

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
- 臨床実験
化学情報
溶剤 & 溶解度
- 体外実験
純度とドキュメンテーション
参考文献

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Neladalkib

生物活性

製品説明

体外実験

体内実験

臨床実験

化学情報

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Neladalkib 関連分類

HY-156467 関連分類

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