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製品番号: HY-119534

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Nicothiazone

Nicothiazone is an α-glucosidase inhibitor with a yeast α-glucosidase IC₅₀ of 120.20 μM. Nicothiazone inhibits α-glucosidase enzyme activity. Nicothiazone can be used for the research of type-II diabetes mellitus.

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CAS 番号: 555-90-8
分子式: C₇H₈N₄S
分子量:180.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nicothiazone 構造式

CAS 番号: 555-90-8

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

α‑glucosidase

120.20 μM (IC₅₀)

体外実験

Nicothiazone (compound 1) (10 min pre-incubation; 30 min reaction incubation) potently inhibits Baker's yeast α-glucosidase with an IC₅₀ of 120.20 μM, showing greater potency than Acarbose (HY-B0089)^[1].
Nicothiazone interacts with Saccharomyces cerevisiae α-glucosidase via hydrogen bonding with residues Asp349 and His111, supporting its inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 555-90-8
分子量 180.23
分子式 C₇H₈N₄S
SMILES

S=C(N)NN=CC=1C=NC=CC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ali F, et al. Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro α-glucosidase inhibitory activity, and in silico studies. European journal of medicinal chemistry. 2017 Sep 29;138:255-272. [Content Brief]

Calculators

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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