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製品番号: HY-117744

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NMS-P645

NMS-P645 is a PIM1 inhibitor. NMS-P645 exhibits anti-proliferative activity when combined with GDC-0941 (HY-50094) in TMPRSS2/ERG positive and negative PCa cells. NMS-P645 can reverse PIM1-induced pro-survival signals in prostate cells. NMS-P645 can be studied in research on prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1482518-95-5
分子式: C₂₈H₃₈ClN₅O₂
分子量:512.09

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NMS-P645 構造式

CAS 番号: 1482518-95-5

容量

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Pim アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>10 μM Compound: 15a	Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
BaF3	IC₅₀	0.125 μM Compound: 15a	Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
CAPAN-1	IC₅₀	3.704 μM Compound: 15a	Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
KMS-11	IC₅₀	7.134 μM Compound: 15a	Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
LNCaP	IC₅₀	3.313 μM Compound: 15a	Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
LP-1	IC₅₀	1.929 μM Compound: 15a	Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
MV4-11	IC₅₀	1.529 μM Compound: 15a	Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
NCI-H929	IC₅₀	5.928 μM Compound: 15a	Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
RPMI-8226	IC₅₀	6.658 μM Compound: 15a	Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]

化学情報

CAS 番号 1482518-95-5
分子量 512.09
分子式 C₂₈H₃₈ClN₅O₂
SMILES

O=C(N[C@@H](C1CCCCC1)CN2CCN(C)CC2)C[C@H]3CNC(C4=CC(C5=CC=CC(Cl)=C5)=CN43)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Mologni, L., et al., (2017). The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition. Journal of Cancer, 8(1), 140-145. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
化学情報
純度とドキュメンテーション
参考文献

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NMS-P645

Pim アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

NMS-P645 関連分類

HY-117744 関連分類