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製品番号: HY-185010

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nor-MC3

Name: nor-MC3
Brand: MedChemExpress
SKU: HY-185010
Price: 246.00 USD
Availability: InStock
Rating: 5 (1 reviews)

カスタマーレビュー

Based on 1 Customer Validation

nor-MC3 is an MC3-type ionizable lipid with C₁₇ unsaturated chains, formulated in lipid nanoparticles for nucleic acid (mRNA and siRNA) delivery and supports in vitro and in vivo transfection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2870681-06-2
分子式: C₄₁H₇₅NO₂
分子量:614.04

保管条件:

Solution, -20°C, 2 years

Data Sheet (263 KB)

nor-MC3 構造式

CAS 番号: 2870681-06-2

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Melanocortin Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

nor-MC3-based mRNA LNPs (0.03-10 μg/mL mRNA; 24 h) exhibit superior in vitro transfection efficiency in HuH7 cells compared to MC3-based LNPs, with enhanced activity at 10 μg/mL mRNA^[1].
nor-MC3-based siRNA LNPs (0.03-1 μg/mL siRNA) exhibit comparable in vitro knockdown efficiency in stably luciferase-expressing 22Rv1 cells to MC3-based LNPs, with enhanced activity at 0.5 μg/mL siRNA and a similar EC₅₀ value of 0.1644 μg/mL siRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Nor-MC3-containing lipid nanoparticles (1 mg/kg mRNA; i.v.; single injection) deliver mRNA to mouse liver and spleen with high efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (6-8 weeks old)^[1]
Dosage:

1 mg/kg mRNA
Administration:

i.v.; single injection
Result:

Exhibited high luminescence intensity per mg liver or spleen tissue.

化学情報

CAS 番号 2870681-06-2
性状 Liquid
分子量 614.04
分子式 C₄₁H₇₅NO₂
SMILES

CN(C)CCCC(OC(CCCCCCC/C=C\C/C=C\CCCCC)CCCCCCC/C=C\C/C=C\CCCCC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Solution, -20°C, 2 years

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (263 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ciufolini M A, et al. MC3-TYPE LIPIDS AND USE THEREOF IN THE PREPARATION OF LIPID NANOPARTICLES. WO/2022/246571. WIPO. 01.12.2022.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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