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United States

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製品番号: HY-P3440A

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NOTA-WL12

NOTA-WL12 is a peptide-based imaging probe targeting PD-L1. NOTA-WL12 is a PD-L1 inhibitory peptide derivative and also a NOTA-conjugated WL12 precursor used for ⁶⁸Ga radiolabeling. The binding of NOTA-WL12 to human and mouse PD-L1 is evaluated by surface plasmon resonance. NOTA-WL12 is predicted by computational docking to interact with PD-L1.

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CAS 番号: 2767203-39-2
分子式: C₁₁₁H₁₅₄N₂₆O₂₆S₂
分子量:2332.70

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-WL12 構造式

CAS 番号: 2767203-39-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

NOTA-WL12 (1 mg/mL; 15 min) is radiolabeled to [¹⁸F]AlF-NOTA-WL12 with a yield of 29% and a radiochemical purity of 97.3%^[2].
NOTA-WL12 (50 µg; 15 min) is radiolabeled with ⁶⁸Ga at 90°C, yielding ⁶⁸Ga-WL12 with a radiochemical purity of > 99% as determined by HPLC^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2767203-39-2
分子量 2332.70
分子式 C₁₁₁H₁₅₄N₂₆O₂₆S₂
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yang Zhang, et al. PET Imaging of Peptide Probe Al[18F]F-NOTA-PCP1 for Monitoring the Engagement of PD-L1 Antibodies in Tumors. Mol. Pharmaceutics 4 March 2024; 21 (3): 1515-1525.

[2]. Ferro-Flores G, et al. Synthesis and Evaluation of [18F]AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [177Lu]Lu-DOTA-iPD-L1. Pharmaceutics. 2025 Jul 16;17(7):920. [Content Brief]

[3]. Li D, et al. Construction of an Iodine-Labeled CS1001 Antibody for Targeting PD-L1 Detection and Comparison with Low-Molecular-Peptide Micro-PET Imaging. Molecular pharmaceutics. 2022 Nov 07;19(11):4382-4389. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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