NP-313
Based on 1 Customer Validation
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.31%
- CAS 番号: 5397-78-4
- 分子式: C12H8ClNO3
- 分子量:249.65
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
1.7 μM
Compound: 5
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Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay
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[PMID: 19101151] |
| SK-BR-3 | IC50 |
0.6 μM
Compound: 5
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Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay
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[PMID: 19101151] |
| SK-BR-3 | IC50 |
6.6 μM
Compound: 5
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Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA
Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA
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[PMID: 19101151] |
NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner. The maximum inhibition of platelet aggregation induced by thrombin and A23187 was approximately 80% and 60%, respectively[1].
NP-313 (0-8 μM) concentration-dependently inhibited P-selectin expression and thromboxane B 2 (TXB2) production in human platelets induced by collagen or thrombin. Also, NP-313 inhibited COX-1 and TXA 2 synthase with the IC 50 values of 1.5 and 3.9 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 5397-78-4
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性状 Solid
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分子量 249.65
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分子式 C12H8ClNO3
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Color Light yellow to yellow
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SMILES
CC(NC(C1=O)=C(Cl)C(C2=C1C=CC=C2)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (100.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0056 mL | 20.0280 mL | 40.0561 mL | 100.1402 mL |
| 5 mM | 0.8011 mL | 4.0056 mL | 8.0112 mL | 20.0280 mL | |
| 10 mM | 0.4006 mL | 2.0028 mL | 4.0056 mL | 10.0140 mL | |
| 15 mM | 0.2670 mL | 1.3352 mL | 2.6704 mL | 6.6760 mL | |
| 20 mM | 0.2003 mL | 1.0014 mL | 2.0028 mL | 5.0070 mL | |
| 25 mM | 0.1602 mL | 0.8011 mL | 1.6022 mL | 4.0056 mL | |
| 30 mM | 0.1335 mL | 0.6676 mL | 1.3352 mL | 3.3380 mL | |
| 40 mM | 0.1001 mL | 0.5007 mL | 1.0014 mL | 2.5035 mL | |
| 50 mM | 0.0801 mL | 0.4006 mL | 0.8011 mL | 2.0028 mL | |
| 60 mM | 0.0668 mL | 0.3338 mL | 0.6676 mL | 1.6690 mL | |
| 80 mM | 0.0501 mL | 0.2504 mL | 0.5007 mL | 1.2518 mL | |
| 100 mM | 0.0401 mL | 0.2003 mL | 0.4006 mL | 1.0014 mL |
NP-313 関連分類
HY-129496 関連分類
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