NPS-467
NPS-467 is a calcium-sensing receptor (CaR) activator and stereospecific agent with only its R-enantiomer active. NPS-467 increases the sensitivity of the CaR to activation by extracellular calcium. NPS-467 stimulates stanniocalcin (STC) secretion in trout and induces inhibition of gill calcium transport in trout. NPS-467 has no effect on serum calcitonin levels in trout.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 148717-47-9
- 分子式: C18H23NO
- 分子量:269.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
NPS-467 (R-enantiomer) (0.25-2.0 mg/kg; i.p.; single dose) produces stereospecific, dose-dependent inhibition of gill calcium transport in fingerling rainbow trout via enhanced STC release, with an ED50 of 0.5 mg/kg, and this effect is fully blocked by fish STC antiserum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Oncorhynchus mykiss (juvenile, 150-250 g)[1]
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Dosage:0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg; 2.0 mg/kg
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Administration:i.p.; single dose
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Result:Produced statistically significant stimulatory effects on STC secretion (P < 0.01-0.001).
Raised serum STC levels maximally to 2069 ng/mL, representing a 9-fold induction over controls; the response plateaued at doses above 2.5 mg/kg.
Achieved an ED50 of 0.44 mg/kg for STC secretion stimulation.
Induced a rapid response, with maximal 14-fold STC induction by 0.5 hours post-injection, which persisted for up to 4 hours.
Showed no statistically significant effects on serum CT levels at doses of 0.25, 0.5, 1.0, or 2.0 mg/kg.
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Animal Model:Oncorhynchus mykiss (fingerling, 1-2 g)[1]
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Dosage:0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg; 2.0 mg/kg
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Administration:i.p.; single dose
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Result:Produced consistent, dose-dependent inhibitory effects on GCAT across three experiments, with statistically significant reductions at all tested doses (P < 0.05-0.01).
Achieved an ED50 of 0.5 mg/kg (2.5 μmol/kg) for GCAT inhibition, which was similar to the ED50 for STC secretion stimulation.
Had its inhibitory effects on GCAT at 2.0 mg/kg completely neutralized by passive immunization with fish STC antiserum, with GCAT rates not significantly different from controls receiving nonimmune rabbit serum alone.
化学情報
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CAS 番号 148717-47-9
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分子量 269.38
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分子式 C18H23NO
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SMILES
CC(NCCCC1=CC=CC=C1)C2=CC(OC)=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NPS-467 関連分類
HY-182543 関連分類
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