NUCC-555
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice.
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- CAS 番号: 1060469-90-0
- 分子式: C25H25N5O3
- 分子量:443.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
12.1 μM
Compound: NUCC-555
|
Induction of apoptosis in human HepG2 cells assessed as cell viability after 96 hrs by MTT assay
Induction of apoptosis in human HepG2 cells assessed as cell viability after 96 hrs by MTT assay
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[PMID: 26098096] |
化学情報
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CAS 番号 1060469-90-0
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分子量 443.50
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分子式 C25H25N5O3
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SMILES
O=C(NCC1=CC=CC=C1)C2=CC(NC(COC)=O)=CC3=C2N(C(C4=CC=CN=C4)=N3)CC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NUCC-555 関連分類
HY-122179 関連分類
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