ORS-14
ORS-14 is a LILRB4/ILT3 ligand with a Kd of 85.2 nM for human receptors. ORS-14 blocks SCG2-mediated LILRB4 signaling pathway, reverses SCG2-mediated immunosuppression, restores cytokine production, reduces tumor cell viability, recovers cytotoxic T cell function, and increases the frequency of granzyme B+ CD8+ T cells. ORS-14 can be used in research related to colorectal cancer and acute myeloid leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1311892-52-0
- 分子式: C17H17N5O2
- 分子量:323.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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LILRB4 85.2 nM (Kd) |
ORS-14 directly binds to the extracellular domain of recombinant human LILRB4, with a KD of 85.2 nM[1].
ORS-14 reverses the immunosuppressive effect mediated by SCG2 in the co-culture system of PBMC and HCT116 colorectal cancer cells, restores cytokine secretion and reduces tumor cell viability[1].
ORS-14 reverses the SCG2-mediated immunosuppressive effect in the co-culture system of PBMC and THP-1 AML, restores IFN-γ secretion, enhances cytotoxic T cell activity, and reduces tumor cell viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1311892-52-0
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分子量 323.35
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分子式 C17H17N5O2
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SMILES
O=C(NCC1=CC=NC(OC2=CC=C(C)C(C)=C2)=C1)C3=CNN=N3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ORS-14 関連分類
HY-184689 関連分類
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