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製品番号: HY-184688

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ORS-22

ORS-22 is an immunomodulator with a K_d value of 9.2 nM for human LILRB4. ORS-22 binds directly to the extracellular domain of LILRB4, reverses immunosuppression, restores cytotoxic T cell function, recovers cytokine production, and reduces tumor cell viability. ORS-22 can be used in research related to colorectal cancer and acute myeloid leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1311612-43-7
分子式: C₁₆H₁₈N₆OS
分子量:342.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ORS-22 構造式

CAS 番号: 1311612-43-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

LILRB4

9.2 nM (Kd)

体外実験

ORS-22 binds directly to recombinant human LILRB4 extracellular domain with a high affinity, exhibiting a K_D of 9.2 nM^[1].
ORS-22 (1 μM; 72 h) restores anti-tumor immune activity in SCG2-suppressed PBMC and HCT116 colorectal cancer co-cultures, enhancing cytokine secretion and reducing tumor cell viability^[1].
ORS-22 (1 μM; 72 h) restores anti-tumor immune activity in SCG2-suppressed PBMC and THP-1 AML co-cultures, enhancing cytokine secretion, activating cytotoxic T cells, and reducing AML cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1311612-43-7
分子量 342.42
分子式 C₁₆H₁₈N₆OS
SMILES

CN(CC(N1CCN2C(C1)=NN=C2C)=O)C3=NC4=C(S3)C=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Abdel-Rahman SA, et al. OracleScreen-LILRB4 (HTS-Oracle v3): machine learning-guided discovery of myeloid immune checkpoint binders validated in patient-derived cells. Bioorganic & medicinal chemistry letters. 2026 Jun 29;140:130717. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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