Oxendolone
Oxendolone (TSAA-291) is a steroidal antiandrogen with partial agonist properties, exhibiting a Ki value of 1.4 nM for the androgen receptor. Oxendolone exerts tissue-specific androgen receptor activity, induces unique androgen receptor conformational changes, and drives differential cofactor recruitment. Oxendolone is recruited to the androgen receptor in a PIAS1-dependent manner. Oxendolone increases levator ani muscle weight in castrated mice. Oxendolone can be used for research on benign prostatic hyperplasia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 33765-68-3
- 分子式: C20H30O2
- 分子量:302.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Oxendolone (0.1 pM-1 μM; 24 h) exhibits tissue-selective androgen receptor agonist activity, with higher relative potency in human skeletal muscle (SkMC) cells (reaching 87.6% of 100 nM DHT activity at 100 nM), whereas in human prostate epithelial (PrEC) cells it is only 47.5% of 100 nM DHT activity (at 100 nM)[1].
Oxendolone (24 h) induces a unique androgen receptor cofactor recruitment profile in 293T cells, recruiting 12 cofactors (including PIAS1) in a manner distinct from DHT, while recruiting 43 cofactors in a ligand-independent manner that is completely consistent with DHT[1].
Oxendolone (100 nM; 24 h) enhances its androgen receptor transcriptional activity in 293T cells through forcibly expressed PIAS1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Crj:ICR (male, 5 weeks old, castrated)[1]
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Dosage:3 mg/kg; 10 mg/kg; 30 mg/kg
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Administration:s.c.; daily; 14 days
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Result:Increased levator ani muscle weight in a dose-dependent manner at 10 mg/kg and 30 mg/kg.
Increased levator ani muscle weight to 78% of that in intact animals at 30 mg/kg.
Showed no marked weight increase in the prostate or seminal vesicle at doses up to 30 mg/kg.
化学情報
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CAS 番号 33765-68-3
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分子量 302.46
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分子式 C20H30O2
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SMILES
C[C@@]12[C@]([C@]3([C@@]([C@@]4(C(CC3)=CC(=O)CC4)[H])(CC1)[H])[H])(C[C@H](CC)[C@@H]2O)[H]
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別名
TSAA-291
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Oxendolone 関連分類
HY-106391 関連分類
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