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United States

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製品番号: HY-139877

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OXS007417

OXS007417 induces differentiation of acute myeloid leukemia cells (EC₅₀ = 48 nM) in vitro and shows antitumor effects in vivo.

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CAS 番号: 2761147-94-6
分子式: C₂₀H₁₄F₃N₃O
分子量:369.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

OXS007417 構造式

CAS 番号: 2761147-94-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

OXS007417 induces differentiation of acute myeloid leukemia cells (EC₅₀ = 48 nM) in vitro and shows antitumor effects in vivo.

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	48 nM Compound: 28; 0X5007417	Induction of differentiation of human HL-60 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis Induction of differentiation of human HL-60 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis	[PMID: 34672555]
OCI-AML-3	EC₅₀	87 nM Compound: 28; 0X5007417	Induction of differentiation of human OCI-AML-3 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis Induction of differentiation of human OCI-AML-3 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis	[PMID: 34672555]
THP-1	EC₅₀	118 nM Compound: 28; 0X5007417	Induction of differentiation of human THP-1 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis Induction of differentiation of human THP-1 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis	[PMID: 34672555]

化学情報

CAS 番号 2761147-94-6
分子量 369.34
分子式 C₂₀H₁₄F₃N₃O
SMILES

FC(F)OC(C=C1)=CC=C1N2C=NC3=CN=C(C4=C(C)C=C(F)C=C4)C=C32
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Josa-Culleré L, et al. A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo. J Med Chem. 2021 Nov 11;64(21):15608-15628. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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