p53 Stabilizer 2
p53 Stabilizer 2 is a 9'-cycloheptylselenomethyl-noscapine derivative and DNA-PKcs-dependent p53 stabilizer with low tubulin-binding affinity.p53 Stabilizer 2 induces S-phase arrest and apoptosis in cancer cells.p53 Stabilizer 2 can be used for the research of cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2531685-87-5
- 分子式: C30H37NO7Se
- 分子量:602.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
p53 Stabilizer 2 (compound 17a16) exerts potent proliferation-inhibitory effects on various tumor cell lines including JeKo-1 and MOLM-13. The IC50 at 48 h (0.81-1.81 μM) is lower than that of normal peripheral blood mononuclear cells, conferring excellent tumor selectivity[1].
p53 Stabilizer 2 increases mitochondrial superoxide levels in A375 and JeKo-1 cells, and induces cellular oxidative stress[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13, NB4, Jurkat, JeKo-1, K562, and A375 cell lines
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Concentration:IC50 assay
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Incubation Time:48 h
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Result:Exhibited IC50 values of 0.92 ± 0.04, 1.81 ± 0.03, 1.36 ± 0.10, 0.97 ± 0.03, 1.71 ± 0.60, and 0.81 ± 0.10 μM against MOLM-13, NB4, Jurkat, JeKo-1, K562, and A375 cell lines, respectively.
化学情報
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CAS 番号 2531685-87-5
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分子量 602.58
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分子式 C30H37NO7Se
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SMILES
O=C1O[C@H]([C@@H]2N(C)CCC3=C(C[Se]C4CCCCCC4)C5=C(OCO5)C(OC)=C23)C6=C1C(OC)=C(OC)C=C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
p53 Stabilizer 2 関連分類
HY-172915 関連分類
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