PCSK9 modulator-3
PCSK9 modulator-3 is a PCSK9 modulator that reduces the secretion level of PCSK9 protein in HepG2 cells. PCSK9 modulator-3 exhibits metabolic stability in liver microsomes of mice and rats. PCSK9 modulator-3 can be used for the study of hyperlipidemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2476490-18-1
- 分子式: C16H9F2N3O
- 分子量:297.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
PCSK9 modulator-3 (compound 13) (1-10 μM; 48 h) reduces the level of secreted PCSK9 protein in HepG2 cells by nearly 90%[1].
PCSK9 modulator-3 exhibits a T1/2 of 30.0 min and a CLint of 46.5 µL/min/mg in mouse liver microsomes, and a T1/2 of 47.8 min and a CLint of 29.4 µL/min/mg in rat liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | AUC0-∞ | Cmax | T1/2 |
|---|---|---|---|---|---|
| Mice[1] | 6.0 mg/kg | i.p. | 695.6 μg/L·h | 294.3 μg/L | 1.64 h |
化学情報
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CAS 番号 2476490-18-1
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分子量 297.26
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分子式 C16H9F2N3O
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SMILES
O=C(C1=NC2=CC=C(F)C=C2N1)C3=CNC4=C3C=CC=C4F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PCSK9 modulator-3 関連分類
HY-146084 関連分類
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