pDI
Based on 1 Customer Validation
pDI is a peptide. pDI inhibits MDM2-p53 and MDMX-p53 interactions with IC50s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.63%
- CAS 番号: 1443628-44-1
- 分子式: C71H99N17O19
- 分子量:1494.65
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 10 nM (MDM2-p53); 100 nM (MDMX-p53)[2]
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1443628-44-1
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性状 Solid
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分子量 1494.65
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分子式 C71H99N17O19
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Color White to off-white
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配列
Leu-Thr-Phe-Glu-His-Tyr-Trp-Ala-Gln-Leu-Thr-Ser-NH2
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シーケンスの短縮
LTFEHYWAQLTS-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (66.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Xu L, et al. Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo. J Med Chem. 2024 Oct 10;67(19):17893-17904. [Content Brief]
[2]. Hu B, et al. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007 Sep 15;67(18):8810-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6691 mL | 3.3453 mL | 6.6905 mL | 16.7263 mL |
| 5 mM | 0.1338 mL | 0.6691 mL | 1.3381 mL | 3.3453 mL | |
| 10 mM | 0.0669 mL | 0.3345 mL | 0.6691 mL | 1.6726 mL | |
| 15 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1151 mL | |
| 20 mM | 0.0335 mL | 0.1673 mL | 0.3345 mL | 0.8363 mL | |
| 25 mM | 0.0268 mL | 0.1338 mL | 0.2676 mL | 0.6691 mL | |
| 30 mM | 0.0223 mL | 0.1115 mL | 0.2230 mL | 0.5575 mL | |
| 40 mM | 0.0167 mL | 0.0836 mL | 0.1673 mL | 0.4182 mL | |
| 50 mM | 0.0134 mL | 0.0669 mL | 0.1338 mL | 0.3345 mL | |
| 60 mM | 0.0112 mL | 0.0558 mL | 0.1115 mL | 0.2788 mL |
pDI 関連分類
HY-P11256 関連分類
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