Penetratin
Based on 1 publication(s) in Google Scholar
Penetratin is a cell-penetrating peptides derived from a nonviral protein. Penetratin can powerfully enhance drug absorption. Penetratin can be used for drug delivery research in the treatment of various diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.98%
- CAS 番号: 940866-75-1
- 分子式: C108H174N36O22S
- 分子量:2360.83
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Penetratin
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生物活性
Penetratin shows low cytotoxicity against NHC cells with an IC50 higher than 2.5 mM[1].
Penetratin (57-285 μM, 1-4 h) increases cellular uptake in NHC cells[1].
Penetratin increases corneal permeation ability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Penetratin (12.5 μM, i.v.) increases the retention of scFvs in LS174T tumor-bearing mice models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 940866-75-1
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性状 Solid
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分子量 2360.83
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分子式 C108H174N36O22S
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Color White to off-white
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配列
Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly
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シーケンスの短縮
RQIKIWFQNRRMKWKKGG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochim Biophys Acta Biomembr
2025 Dec 29:184496. PMID: 41475484
溶剤 & 溶解度
H2O : 100 mg/mL (42.36 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Liu C, et al. Penetratin, a potentially powerful absorption enhancer for noninvasive intraocular drug delivery. Mol Pharm. 2014 Apr 7;11(4):1218-27. [Content Brief]
[2]. Jain M, et al. Penetratin improves tumor retention of single-chain antibodies: a novel step toward optimization of radioimmunotherapy of solid tumors. Cancer Res. 2005 Sep 1;65(17):7840-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.4236 mL | 2.1179 mL | 4.2358 mL | 10.5895 mL |
| 5 mM | 0.0847 mL | 0.4236 mL | 0.8472 mL | 2.1179 mL | |
| 10 mM | 0.0424 mL | 0.2118 mL | 0.4236 mL | 1.0589 mL | |
| 15 mM | 0.0282 mL | 0.1412 mL | 0.2824 mL | 0.7060 mL | |
| 20 mM | 0.0212 mL | 0.1059 mL | 0.2118 mL | 0.5295 mL | |
| 25 mM | 0.0169 mL | 0.0847 mL | 0.1694 mL | 0.4236 mL | |
| 30 mM | 0.0141 mL | 0.0706 mL | 0.1412 mL | 0.3530 mL | |
| 40 mM | 0.0106 mL | 0.0529 mL | 0.1059 mL | 0.2647 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Penetratin 関連分類
HY-P2529 関連分類
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