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United States

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製品番号: HY-108327

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PF-05020182

PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC₅₀ of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1354712-92-7
分子式: C₁₈H₃₀N₄O₄
分子量:366.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PF-05020182 構造式

CAS 番号: 1354712-92-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	1327 nM Compound: 2, PF-05020182	Activation of rat Kv7.3/7.5 expressed in CHOK1 cells Activation of rat Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	294 nM Compound: 2, PF-05020182	Activation of rat Kv7.2/7.3 expressed in CHOK1 cells Activation of rat Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	334 nM Compound: 2, PF-05020182	Activation of human Kv7.2/7.3 expressed in CHOK1 cells Activation of human Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	376 nM Compound: 2, PF-05020182	Activation of rat Kv7.4 expressed in CHOK1 cells Activation of rat Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	588 nM Compound: 2, PF-05020182	Activation of human Kv7.3/7.5 expressed in CHOK1 cells Activation of human Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	625 nM Compound: 2, PF-05020182	Activation of human Kv7.4 expressed in CHOK1 cells Activation of human Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	>100000 nM Compound: 2, PF-05020182	Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells	[PMID: 25987375]

化学情報

CAS 番号 1354712-92-7
分子量 366.46
分子式 C₁₈H₃₀N₄O₄
SMILES

O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(CC2)OC)N=C1OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Davoren JE, et al., Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4941-4944. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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