PF-7006
PF-7006 is an Mps1 kinase inhibitor with a Ki value of 0.27 nM and an IC50 value of 2.5 nM. PF-7006 interferes with cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reducing histone H3 levels, and shortening the duration of mitosis, leading to apoptosis in cancer cells. Combined use of PF-7006 with Palbociclib (HY-50767) increases cancer cell tolerance to PF-7006. PF-7006 can be used for breast cancer research.
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- CAS 番号: 2771955-09-8
- 分子式: C22H26N8O2
- 分子量:434.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50：2.5 nM (Mps1) [1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
2 nM
Compound: 38; PF-7006
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Antiproliferative activity against human MDA-MB-231 cells after 7 days by cell titer-glo assay
Antiproliferative activity against human MDA-MB-231 cells after 7 days by cell titer-glo assay
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[PMID: 31121430] |
化学情報
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CAS 番号 2771955-09-8
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分子量 434.49
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分子式 C22H26N8O2
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SMILES
N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC5CCOCC5)=C12
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PF-7006 関連分類
HY-164519 関連分類
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