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製品番号: HY-187648

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pNPPT cyclohexanamine

Name: pNPPT cyclohexanamine
Brand: MedChemExpress
SKU: HY-187648
Availability: PreOrder

(別名: p-Nitrophenyl phosphorothioate cyclohexanamine)

pNPPT cyclohexanamine (p-Nitrophenyl phosphorothioate cyclohexanamine) is a dianionic aryl thiophosphate monoester substrate of PP1γ (protein phosphatase 1γ). PP1γ catalyzes the hydrolysis of pNPPT cyclohexanamine.

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CAS 番号: 167698-72-8
分子式: C₁₈H₃₂N₃O₅PS
分子量:433.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

pNPPT cyclohexanamine 構造式

CAS 番号: 167698-72-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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製品説明

体外実験

pNPPT (compound 2a) cyclohexanamine is efficiently hydrolyzed by wild-type PP1γ, with a maximum catalytic efficiency of 31 M^-1s^-1 and a second-order rate acceleration ratio of 1.7 × 10¹¹. The transition state is characterized by restricted leaving group bond cleavage and effective general acid neutralization of the leaving group. The hydrolysis catalytic efficiency decreases for the PP1 R96K and PP1 R221K single mutants of PP1γ, with corresponding catalytic efficiency values of 0.8 M^-1s^-1 and 1.9 M^-1s^-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

化学情報

CAS 番号 167698-72-8
分子量 433.50
分子式 C₁₈H₃₂N₃O₅PS
SMILES

O=P(O)(S)OC(C=C1)=CC=C1[N+]([O-])=O.NC2CCCCC2.NC3CCCCC3
別名

p-Nitrophenyl phosphorothioate cyclohexanamine
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Chu Y, et al. Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1. Biochemistry, 2017, 56(30): 3923-3933.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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