Polycarbophil
Based on 1 Customer Validation
Polycarbophil is an orally active hydrophilic polymer. Polycarbophil achieves bioadhesion through hydrogen bonding between carboxyl groups and mucosal surfaces, and prolongs compound retention time and regulates compound release through swelling properties. Polycarbophil relieves constipation and diarrhea.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 9003-97-8
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Polycarbophil (0.5%-1.0% w/v; 25-120 min) increases the apparent permeability of Pipemidic acid (HY-B1210) by 2.3-4.3 times in isolated porcine urinary bladder wall, primarily due to enhanced urothelium permeability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Polycarbophil (500-1000 mg/kg; p.o.; before constipation inducer) restores fecal weight and relieves constipation in Loperamide (HY-156131)/Clonidine (HY-12721)-induced constipated rats[3].
Polycarbophil (500-1000 mg/kg; p.o.; before stress) reduces stress-induced fecal output in wrap restraint stress (WRS)-induced defecation rats[3].
Polycarbophil (500-1000 mg/kg; p.o.; before diarrhea inducer) suppresses Castor oil (HY-107799)-induced diarrhea in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 9003-97-8
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性状 Solid
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Color White to off-white
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SMILES
[Polycarbophil]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Grabnar I, et al. Influence of chitosan and polycarbophil on permeation of a model hydrophilic drug into the urinary bladder wall. Int J Pharm. 2003 Apr 30;256(1-2):167-73. [Content Brief]
[3]. Saito T, et al. Laxative and anti-diarrheal activity of polycarbophil in mice and rats. Jpn J Pharmacol. 2002 Jun;89(2):133-41. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Polycarbophil 関連分類
HY-154659 関連分類
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