ROR1
null ROR1, receptor tyrosine kinase-like orphan receptor 1, combines an extracellular immunoglobulin-like domain, a frizzled-like cysteine-rich domain, and a kringle domain with an intracellular kinase whose activity is weak or ligand-independent. During embryogenesis ROR1 orchestrates WNT5A-dependent cell migration and polarity, but expression is silenced in most adult tissues. It reappears prominently in chronic lymphocytic leukemia, mantle cell lymphoma, and various solid tumors, where it supports survival and epithelial-mesenchymal transition. This oncofetal pattern has made ROR1 one of the most actively pursued CAR-T and antibody targets in hematologic malignancies. Monoclonal antibodies such as the ADC zilovertamab vedotin have been developed against ROR1.
-
ROR1 組換えタンパク質 (11)
- 生物種:
- 由来:
- 生物種:
- 由来:
- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
