PSB-1410
Based on 1 Customer Validation
PSB-1410 is a monoamine oxidase B (MAO-B) inhibitor, with an IC50 of 0.227 nM against human MAO-B and an IC50 of 1.01 nM against rat MAO-B. PSB-1410 can be used for the research of Parkinson's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.22%
- CAS 番号: 1494477-03-0
- 分子式: C15H10Cl2N2O
- 分子量:305.16
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
hMAO-B 0.227 nM (IC50) |
rMAO-B 1.01 nM (IC50) |
体外実験
PSB-1410 (Compound 53) potently and selectively inhibits human MAO-B with an IC50 of 0.227 nM, and rat MAO-B with an IC50 of 1.01 nM, while only weakly inhibiting human and rat MAO-A[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1494477-03-0
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性状 Solid
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分子量 305.16
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分子式 C15H10Cl2N2O
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Color White to off-white
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SMILES
O=C(C1=CC2=C(NC=C2)C=C1)NC3=CC=C(Cl)C(Cl)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (409.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2770 mL | 16.3848 mL | 32.7697 mL | 81.9242 mL |
| 5 mM | 0.6554 mL | 3.2770 mL | 6.5539 mL | 16.3848 mL | |
| 10 mM | 0.3277 mL | 1.6385 mL | 3.2770 mL | 8.1924 mL | |
| 15 mM | 0.2185 mL | 1.0923 mL | 2.1846 mL | 5.4616 mL | |
| 20 mM | 0.1638 mL | 0.8192 mL | 1.6385 mL | 4.0962 mL | |
| 25 mM | 0.1311 mL | 0.6554 mL | 1.3108 mL | 3.2770 mL | |
| 30 mM | 0.1092 mL | 0.5462 mL | 1.0923 mL | 2.7308 mL | |
| 40 mM | 0.0819 mL | 0.4096 mL | 0.8192 mL | 2.0481 mL | |
| 50 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6385 mL | |
| 60 mM | 0.0546 mL | 0.2731 mL | 0.5462 mL | 1.3654 mL | |
| 80 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0241 mL | |
| 100 mM | 0.0328 mL | 0.1638 mL | 0.3277 mL | 0.8192 mL |
PSB-1410 関連分類
HY-123665 関連分類
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