(R)-OY-101
(R)-OY-101 is an orally active and specific inhibitor of P-gp. (R)-OY-101 increases tumor sensitivity to anticancer agents. (R)-OY-101 has good activity in reversing tumor resistance and promoting apoptosis and can be used in cancer related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 23495-82-1
- 分子式: C27H31NO4
- 分子量:433.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
(R)-OY-101 increases the cytotoxicity of Vincristine (HY-N0488A) on Eca109/VCR cells with an IC50 value of 9.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Notes: (R)-OY-101 is a stereoscopic configuration of OY-101.
| Administration manner | Tmax (h) | Cmax (ng/mL) | λz (1/h) | T1/2 (h) | MRT0-inf (h) | AUC0-t (ng /mL•h) | AUC0-inf (ng /mL•h) | AUMC0-inf (ng /mL•h2) | Vz/F (L/kg) | Cl/F (L/kg/h) | F (%) |
| Intravenous injection | 0.17±0.12 | 1573.20±143.97 | 0.15±0.13 | 8.43±7.83 | 2.68±0.47 | 2688.45±180.10 | 2742.45±218.99 | 7391.35±1874.05 | 12.84±11.33 | 1.10±0.08 | |
| Oral gavage | 0.38±0.18 | 636.55±355.60 | 0.12±0.08 | 7.37±4.92 | 4.89±1.01 | 2665.45±450.92 | 2737.40±515.20 | 131110.55±237.09 | 111.27±56.82 | 11.16±2.10 | 7.65±2.15 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 23495-82-1
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分子量 433.54
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分子式 C27H31NO4
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SMILES
CN1[C@H](CC2=CC=C(OC)C(OCC3=CC=CC=C3)=C2)C4=C(C=C(OC)C(OC)=C4)CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(R)-OY-101 関連分類
HY-149053B 関連分類
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